Micky van de Ven Double Halts The Toffees' Run at New Stadium
The Dutch defender emerged as the initial backline player to net two goals in a English top-flight match for Tottenham since Jan Vertonghen in March 2013.
Key points
The Spurs defender heads home twice in opening period
The home side's Jake O'Brien has equalizer ruled after VAR review
Pape Matar Sarr nets final goal in 89th minute
The defeat is the Merseyside club's first at their new ground
The Tottenham defender scored on two occasions as Tottenham extended their unbeaten run in away games in the Premier League and handed the Toffees their first defeat at their new home.
Everton were undefeated in their last five matches at their recently opened stadium at the dockside location, having left their historic home behind after more than a century at the conclusion of the previous campaign.
But Tottenham's leader the Dutchman struck twice from corners in the first half to place their strong form at risk, and they were unable to mount a comeback before Pape Matar Sarr - assisted by ex-Everton forward the Brazilian - nodded in a third to seal the victory.
Jake O'Brien thought he had levelled the tally five minutes after Van de Ven's opener, directing a bullet header past Guglielmo Vicario from an Everton corner.
Beto, in the meantime, failed to convert a handful of chances, while Vicario made a series of fine stops to guarantee the London club went five matches on the road without defeat in the Premier League.
But the VAR stepped in, instructing Craig Pawson to check the goal on the screen and the referee decided that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
The win moves Thomas Frank's team up to third in the Premier League, a handful of points off local foes and table-toppers Arsenal.
The Merseyside club remain in 14th position and sit six points clear of the drop zone.
Spurs breakdown: Van de Ven excels in duties at both ends of the field
Following a drab midweek display in the Champions League against the French side, where they managed a mere two shots on goal, the manager chose Randal Kolo Muani in attack instead of former Toffees player the Brazilian.
The new arrival was failed to influence the game before being replaced for Richarlison after 60 minutes on the pitch, but it emerged he wasn't needed in the end.
Centre-back the Dutchman transformed into an attacking force to be reckoned with.
Spurs' opening strike came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an unmarked the defender to score.
And Ven de Ven - filling in as captain in Cristian Romero's absence - added his second in first-half stoppage time as he outjumped the England keeper to nod in.
The Dutchman was equally impressive in defensive duties, partnering effectively with Kevin Danso as the pair dealt excellently with the numerous deliveries sent their way by Everton.
Everton analysis: Toffees lacking finishing touch
The club's recent stadium had been a fortress, but it appears the novelty may have worn off slightly and supporters flocked to the exits after Sarr's third for Tottenham.
The end in the team's unbeaten home run won't be a massive concern for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Everton's two established strikers - had scored just a single goal between them before the weekend's match.
And they were failed to add to that miserable record on a wet and gloomy night on Merseyside.
Beto's form was summed up when he opted to overhead kick a golden opportunity from near the goal, despite having space and opportunity to reposition for a more conventional attempt that would have tested the keeper.
The substitute, as well, failed to make an impact after coming on for Beto in the 65th minute.
It was not for a shortage of opportunity. The majority of Everton's attacks came through Grealish and the forward, who relentlessly delivered dangerous crosses into the Tottenham penalty area.
Upcoming fixtures for these two sides?
Everton: Moyes' men head to Sunderland in the Premier League on Monday, 3 November at 20:00 GMT.
Spurs: Spurs travel to St James' Park on Wednesday, 29 October for their fourth-round Carabao Cup tie against Newcastle.